Endocrine Abstracts

Introduction: Recent studies claim that microRNAs (miRNAs) participate in the pathogenesis of coronary artery disease (CAD).Objective: To study miRNA expression in patients with obesity, determine their association with CAD.Methods: MiRNAs were detected in peripheral blood. 66 patients with BMI 30.0–39.9 kg/m2 were divided into 3 groups: 1st – with CAD and T2DM, 2nd – with T2DM and excluded CAD, 3rd –...

Aim: To study the morphofunctional state of the myocardium in young people with diabetes mellitus 1 using magnetic resonance imaging (MRI) technology.Material and methods: 38 patients (14 men, 24 women), aged 18–36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive mri of the heart. The exclusion criteria were: pronounced electrolyte disorders in the blood, dysproteinemia, chronic liver and kidney fail...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are commonly associated with coronary artery disease (CAD). Recent studies demonstrated that microRNAs (miRNAs) are involved in the pathogenesis of CAD.Aim: To study miRNA-26a, microRNA-33a and microRNA-33b expression in patients with obesity.Methods: MiRNAs were detected in peripheral blood samples of 66 patients, aged 48–65 years. Patients with BMI 30.0–39.9 kg/m...

Introduction: Obesity and diabetes mellitus type 2 (T2DM) are considered as one of the major risk factor for coronary heart disease (CHD) development, but the mechanisms beyond this relationship still need to be clarified. miRNAs are supposed to be involved in regulatory mechanisms in this relationship.Aim: To determine miRNAs expression in patients with obesity and T2DM.Methods: MiRNAs were detected in peripheral blood of 43 patie...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are associated with cardiovascular diseases (CVD). Fibrotic changes in obesity include several molecular processes, including activation of Transforming growth factor β (TGF-β). Recent data indicate the involvement of Fibroblast growth factor 21 (FGF-21) as an important metabolic regulator, and even biomarker of metabolic changes in obesity and T2DM.Aim: To determine TGF-β and FGF-2...

Aim: To study the distribution of epicardial fat in young people with type 1 diabetes mellitus using magnetic resonance imaging (MRI) technologies.Material and Methods: 60 patients (29 men, 31 women), aged 18 to 36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive cardio MRI. Measurements of epicardial fat (EF) were carried out on basal (B), medium (M), apical (A) segments of the left (LV) and right ventri...

Background: Patients with type 1 diabetes have a significantly higher risk of coronary events, as well as diseases of the cardiovascular system.Purpose of the study – to show the relationship between metabolic, structural, and functional parameters of the cardiovascular system in young patients with DM1.Methods: The study included 60 patients without CVD: 40 patients with DM1 and 20 patients without DM1, the groups were comparable in age, sex, AMT, ...